Cyclin B3

CCNB3
Identifiers
Aliases	CCNB3, cyclin B3, CYCB3
External IDs	OMIM: 300456; MGI: 2183443; HomoloGene: 13199; GeneCards: CCNB3; OMA:CCNB3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	50,351,914 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	6,907,858 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; secondary oocyte; ; right testis; ; left testis; ; C1 segment; ; ventricular zone; ; right uterine tube; ; olfactory zone of nasal mucosa; ; islet of Langerhans;
	Top expressed in
	seminiferous tubule; ; blastocyst; ; zygote; ; secondary oocyte; ; primary oocyte; ; morula; ; spermatid; ; spermatocyte; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity;
Cellular component	nucleus; nuclear speck; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; centrosome;
Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity; cell cycle; cell division; meiosis; regulation of G2/M transition of mitotic cell cycle; mitotic cell cycle; protein phosphorylation; regulation of mitotic nuclear division; positive regulation of cell population proliferation; positive regulation of cell cycle; mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	85417
	209091
	ENSG00000147082
	ENSMUSG00000051592
	Q8WWL7
	Q810T2
	NM_033031; NM_033670; NM_033671
	NM_183015
	NP_149020; NP_391990
	NP_898836
	Wikidata
View/Edit Human	View/Edit Mouse

G2/mitotic-specific cyclin-B3 is a protein encoded by the CCNB3 gene located on the X chromosome in humans. Cyclin B3 has features of both A type cyclins and B type cyclins and is a distinct subfamily of B type cyclins conserved across many species. However, human cyclin B3 is considerably larger than all other previously characterized invertebrate or vertebrate cyclin B3s. Unlike cyclin B1 and cyclin B2, it is solely expressed in germ cells in mammals, with a significant role in meiosis and gamete formation.