CCT6B

CCT6B
Identifiers
Aliases	CCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDs	OMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	34,981,078 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	82,655,147 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; gonad; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; gastrocnemius muscle; ; palpebral conjunctiva; ; gastric mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; blastocyst; ; embryo; ; Ileal epithelium; ; embryo; ; morula; ; morula; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATP binding; protein folding chaperone activity; unfolded protein binding;
Cellular component	cytoplasm; cytosol; chaperonin-containing T-complex;
Biological process	toxin transport; protein folding; chaperone-mediated protein complex assembly; spermatogenesis; protein transport; 'de novo' protein folding; chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologs
	10693
	12467
	ENSG00000132141
	ENSMUSG00000020698
	Q92526
	Q61390
	NM_001193529; NM_001193530; NM_006584
	NM_001291242; NM_009839
	NP_001180458; NP_001180459; NP_006575
	NP_001278171; NP_033969
	Wikidata
View/Edit Human	View/Edit Mouse

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.