Granulocyte-macrophage colony-stimulating factor receptor

CSF2RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NKQ, 4RS1
Identifiers
Aliases	CSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, colony stimulating factor 2 receptor alpha subunit, alphaGMR, colony stimulating factor 2 receptor subunit alpha, GMR-alpha, GMCSFR-alpha, granulocyte-macrophage colony-stimulating factor receptor
External IDs	OMIM: 425000, 306250; MGI: 1339754; HomoloGene: 48406; GeneCards: CSF2RA; OMA:CSF2RA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	1,310,381 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	61,228,429 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; placenta; ; sural nerve; ; right lung; ; testicle; ; upper lobe of left lung; ; C1 segment; ; appendix;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; stroma of bone marrow; ; neural layer of retina; ; genital tubercle; ; superior frontal gyrus; ; blood; ; subcutaneous adipose tissue; ; primary visual cortex; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor activity; protein tyrosine kinase activity; signaling receptor activity; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; intracellular anatomical structure; external side of plasma membrane; receptor complex;
Biological process	MAPK cascade; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1438
	12982
	ENSG00000198223
	ENSMUSG00000059326
	P15509
	Q00941
NM_001161529; NM_001161530; NM_001161531; NM_001161532; NM_006140;
	NM_172245; NM_172246; NM_172247; NM_172248; NM_172249; NM_001379153; NM_001379154; NM_001379155; NM_001379156; NM_001379158; NM_001379159; NM_001379160; NM_001379161; NM_001379162; NM_001379163; NM_001379164; NM_001379165; NM_001379166; NM_001379167; NM_001379168; NM_001379169
	NM_009970
NP_001155001; NP_001155002; NP_001155003; NP_001155004; NP_006131;
	NP_758448; NP_758449; NP_758450; NP_758452; NP_001366082; NP_001366083; NP_001366084; NP_001366085; NP_001366087; NP_001366088; NP_001366089; NP_001366090; NP_001366091; NP_001366092; NP_001366093; NP_001366094; NP_001366095; NP_001366096; NP_001366097; NP_001366098
	NP_034100
	Wikidata
View/Edit Human	View/Edit Mouse

The granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development.

It is associated with Surfactant metabolism dysfunction type 4.