CD163

CD163
Identifiers
Aliases	CD163, M130, MM130, SCARI1, CD163 molecule
External IDs	OMIM: 605545; MGI: 2135946; HomoloGene: 128811; GeneCards: CD163; OMA:CD163 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,503,893 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,307,486 bp
RNA expression pattern
	Top expressed in
	right lung; ; gastric mucosa; ; lower lobe of lung; ; right adrenal cortex; ; spleen; ; left adrenal cortex; ; monocyte; ; left uterine tube; ; right coronary artery; ; pericardium;
	Top expressed in
	stroma of bone marrow; ; lumbar spinal ganglion; ; aortic valve; ; skin of external ear; ; ascending aorta; ; sciatic nerve; ; white adipose tissue; ; intercostal muscle; ; ankle; ; tunica adventitia of aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; protein binding;
Cellular component	integral component of membrane; extracellular region; endocytic vesicle membrane; integral component of plasma membrane; membrane; plasma membrane; external side of plasma membrane;
Biological process	inflammatory response; acute-phase response; receptor-mediated endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9332
	93671
	ENSG00000177575
	ENSMUSG00000008845
	Q86VB7
	Q2VLH6
	NM_004244; NM_203416; NM_001370145; NM_001370146
	NM_001170395; NM_053094
	NP_004235; NP_981961; NP_001357074; NP_001357075
	NP_001163866; NP_444324
	Wikidata
View/Edit Human	View/Edit Mouse

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. The receptor was discovered in 1987.