SIRPG

SIRPG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JJW, 4I2X
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466; MGI: 108563; HomoloGene: 56809; GeneCards: SIRPG; OMA:SIRPG - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,657,779 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	129,474,148 bp
RNA expression pattern
	Top expressed in
	thymus; ; testicle; ; lymph node; ; granulocyte; ; blood; ; appendix; ; spleen; ; mucosa of transverse colon; ; left testis; ; right testis;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; prefrontal cortex; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; tibiofemoral joint; ; perirhinal cortex; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure;
Biological process	cell-cell signaling; cell adhesion; intracellular signal transduction; positive regulation of T cell activation; leukocyte migration; positive regulation of cell population proliferation; negative regulation of cell population proliferation; positive regulation of cell-cell adhesion; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55423
	19261
	ENSG00000089012
	ENSMUSG00000037902
	Q9P1W8
	P97797
	NM_001039508; NM_018556; NM_080816
NM_001177646; NM_001177647; NM_001291019; NM_001291020; NM_001291021;
	NM_001291022; NM_007547; NM_001355158; NM_001355160
	NP_001034597; NP_061026; NP_543006
NP_001171118; NP_001277948; NP_001277949; NP_001277950; NP_001277951;
	NP_031573; NP_001342087; NP_001342089
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.