CD177

CD177
Identifiers
Aliases	CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDs	OMIM: 162860; MGI: 1916141; HomoloGene: 49628; GeneCards: CD177; OMA:CD177 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	43,363,172 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,459,736 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of colon; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; bone marrow; ; bone marrow cells; ; spleen; ; trabecular bone; ; prostate; ; blood;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; primary oocyte; ; secondary oocyte; ; zygote; ; large intestine; ; colon; ; left colon; ; bone marrow; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protease binding; integrin binding; calcium-dependent protein binding;
Cellular component	anchored component of membrane; extracellular exosome; membrane; specific granule membrane; plasma membrane; secretory granule membrane; plasma membrane raft; tertiary granule membrane; extracellular region; lamellipodium; cell projection; membrane raft;
Biological process	blood coagulation; leukocyte migration; neutrophil degranulation; cell adhesion; leukocyte cell-cell adhesion; regulation of endocytosis; positive regulation of superoxide anion generation; protein localization to cell surface; positive regulation of neutrophil degranulation; cell-cell junction maintenance; neutrophil extravasation; cell-cell adhesion via plasma-membrane adhesion molecules; neutrophil migration; regulation of integrin-mediated signaling pathway; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	57126
	68891
	ENSG00000204936
	ENSMUSG00000052212
	Q8N6Q3
	Q8R2S8
	NM_020406
	NM_026862
	NP_065139
	NP_081138
	Wikidata
View/Edit Human	View/Edit Mouse

CD177 antigen is a protein that in humans is encoded by the CD177 gene.

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM]