Integrin beta 2

ITGB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Identifiers
Aliases	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
External IDs	OMIM: 600065; MGI: 96611; HomoloGene: 20092; GeneCards: ITGB2; OMA:ITGB2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,931,989 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,401,542 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; bone marrow cells; ; appendix; ; trabecular bone; ; lymph node; ; right lung; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; spleen; ; thymus; ; mesenteric lymph nodes; ; blood; ; right lung lobe; ; ankle joint; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; metal ion binding; protein binding; protein heterodimerization activity; ICAM-3 receptor activity; protein kinase binding; cell adhesion molecule binding; heat shock protein binding; amyloid-beta binding; complement component C3b binding; integrin binding; signaling receptor activity; cargo receptor activity;
Cellular component	integral component of membrane; extracellular vesicle; integrin alphaL-beta2 complex; membrane; plasma membrane; receptor complex; cell surface; integrin complex; extracellular exosome; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane; focal adhesion; external side of plasma membrane; integrin alphaM-beta2 complex; plasma membrane raft; membrane raft; cytoplasmic region; protein-containing complex;
Biological process	leukocyte cell-cell adhesion; endodermal cell differentiation; toll-like receptor 4 signaling pathway; positive regulation of nitric oxide biosynthetic process; heterotypic cell-cell adhesion; cell-cell signaling; ageing; receptor internalization; leukocyte migration involved in inflammatory response; natural killer cell activation; cellular response to low-density lipoprotein particle stimulus; extracellular matrix organization; receptor clustering; positive regulation of angiogenesis; neutrophil chemotaxis; cell adhesion; positive regulation of NF-kappaB transcription factor activity; regulation of cell shape; regulation of immune response; cellular extravasation; integrin-mediated signaling pathway; cell-matrix adhesion; inflammatory response; endothelial cell migration; leukocyte migration; regulation of peptidyl-tyrosine phosphorylation; apoptotic process; phagocytosis; neutrophil degranulation; microglial cell activation; receptor-mediated endocytosis; phagocytosis, engulfment; cell migration; cytokine-mediated signaling pathway; positive regulation of superoxide anion generation; cell adhesion mediated by integrin; positive regulation of neutrophil degranulation; negative regulation of dopamine metabolic process; positive regulation of protein targeting to membrane; amyloid-beta clearance; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; positive regulation of neuron death; positive regulation of microglial cell activation; neutrophil migration; positive regulation of prostaglandin-E synthase activity; positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
Orthologs
	3689
	16414
	ENSG00000160255
	ENSMUSG00000000290
	P05107
	P11835
	NM_000211; NM_001127491; NM_001303238
	NM_008404
	NP_000202; NP_001120963; NP_001290167
	NP_032430
	Wikidata
View/Edit Human	View/Edit Mouse

In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses. CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders.