C-C chemokine receptor type 6

CCR6
Identifiers
Aliases	CCR6, BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22, C-C motif chemokine receptor 6
External IDs	OMIM: 601835; MGI: 1333797; HomoloGene: 3214; GeneCards: CCR6; OMA:CCR6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	167,139,141 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	8,475,973 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; testicle; ; granulocyte; ; blood; ; duodenum; ; gallbladder; ; rectum; ; tonsil;
	Top expressed in
	spleen; ; lymph node; ; mesenteric lymph nodes; ; blood; ; subcutaneous adipose tissue; ; spermatid; ; embryo; ; embryo; ; thymus; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; chemokine receptor activity; protein binding; C-C chemokine receptor activity; C-C chemokine binding; signaling receptor activity; chemokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; cell surface; sperm midpiece; sperm flagellum; sperm principal piece; sperm plasma membrane; external side of plasma membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; positive regulation of epithelial cell migration; dendritic cell chemotaxis; cellular defense response; humoral immune response; immune response; positive regulation of dendritic cell chemotaxis; signal transduction; calcium-mediated signaling; chemotaxis; cell chemotaxis; chemokine-mediated signaling pathway; leukocyte migration involved in inflammatory response; isotype switching to IgA isotypes; positive regulation of flagellated sperm motility involved in capacitation; lymphocyte migration; T cell migration; thymocyte migration; DN2 thymocyte differentiation; DN3 thymocyte differentiation; regulation of T cell migration; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1235
	12458
	ENSG00000112486
	ENSMUSG00000040899
	P51684
	O54689
	NM_031409; NM_004367; NM_001394582
NM_001190333; NM_001190334; NM_001190335; NM_001190336; NM_001190337;
	NM_001190338; NM_009835
	NP_004358; NP_113597
NP_001177262; NP_001177263; NP_001177264; NP_001177265; NP_001177266;
	NP_001177267; NP_033965
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).