CD200R1

CD200R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BFG, 4BFI
Identifiers
Aliases	CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
External IDs	OMIM: 607546; MGI: 1889024; HomoloGene: 10957; GeneCards: CD200R1; OMA:CD200R1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,975,103 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	44,615,341 bp
RNA expression pattern
	Top expressed in
	testicle; ; epithelium of nasopharynx; ; nasal epithelium; ; bone marrow cells; ; granulocyte; ; monocyte; ; lymph node; ; appendix; ; spleen; ; gallbladder;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; calvaria; ; pharynx; ; right lobe of liver; ; embryo; ; lumbar spinal ganglion; ; dermis; ; blood; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; immunoglobulin receptor activity; signaling receptor activity; glycosylated region protein binding;
Cellular component	integral component of membrane; extracellular region; receptor complex; membrane; external side of plasma membrane; plasma membrane; cell surface;
Biological process	viral process; regulation of immune response; signal transduction; heterotypic cell-cell adhesion; intracellular signal transduction; Fc receptor signaling pathway; regulation of neuroinflammatory response; negative regulation of neuroinflammatory response; negative regulation of neuron death; negative regulation of macrophage migration; negative regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	131450
	57781
	ENSG00000163606
	ENSMUSG00000022667
	Q8TD46
	Q9ES57
	NM_138806; NM_138939; NM_138940; NM_170780
	NM_021325
	NP_620161; NP_620385; NP_620386; NP_740750
	NP_067300
	Wikidata
View/Edit Human	View/Edit Mouse

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. CD200R1 is expressed on the surface of myeloid cells and CD4+ T cells. It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons, epithelial cells, endothelial cells, fibroblasts, and lymphoid cells.

CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), interferons, and inducible nitric oxide synthase (iNOS).