CD226

CD226
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6ISA, 6ISC, 6ISB, 6O3O
Identifiers
Aliases	CD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule
External IDs	OMIM: 605397; MGI: 3039602; HomoloGene: 4787; GeneCards: CD226; OMA:CD226 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	69,961,803 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	89,290,353 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; lymph node; ; gonad; ; testicle; ; spleen; ; appendix; ; sural nerve; ; epithelium of colon;
	Top expressed in
	blood; ; zygote; ; spleen; ; thymus; ; mesenteric lymph nodes; ; embryo; ; bone marrow; ; secondary oocyte; ; subcutaneous adipose tissue; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; protein kinase binding; integrin binding; cell adhesion molecule binding;
Cellular component	integral component of plasma membrane; membrane raft; integral component of membrane; membrane; cell surface; external side of plasma membrane; plasma membrane;
Biological process	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; cell adhesion; regulation of immune response; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of Fc receptor mediated stimulatory signaling pathway; cell recognition; cytokine production; positive regulation of immunoglobulin mediated immune response; signal transduction; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of mast cell activation; positive regulation of interferon-gamma production; positive regulation of natural killer cell cytokine production; positive regulation of T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10666
	225825
	ENSG00000150637
	ENSMUSG00000034028
	Q15762
	Q8K4F0
	NM_001303618; NM_001303619; NM_006566
	NM_001039148; NM_001039149; NM_178687
	NP_001290547; NP_001290548; NP_006557
	NP_001034238; NP_848802
	Wikidata
View/Edit Human	View/Edit Mouse

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a ~65 kDa immunoglobulin-like transmembrane glycoprotein expressed on the surface of natural killer cells, NK T cell, B cells, dendritic cells, hematopoietic precursor cells, platelets, monocytes and T cells.

DNAM-1 gene CD226 is conserved between human and mice. In humans the CD226 gene is located on chromosome 18q22.3. In mice the CD226 gene is located on chromosome 18E4.