Duffy antigen system

ACKR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NUU, 4NUV
Identifiers
Aliases	ACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC, DARC/ACKR1
External IDs	OMIM: 613665; MGI: 1097689; HomoloGene: 48067; GeneCards: ACKR1; OMA:ACKR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,206,500 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	173,161,317 bp
RNA expression pattern
	Top expressed in
	vena cava; ; left uterine tube; ; gastric mucosa; ; subcutaneous adipose tissue; ; pericardium; ; tibial nerve; ; olfactory zone of nasal mucosa; ; ectocervix; ; coronary artery; ; canal of the cervix;
	Top expressed in
	cerebellar cortex; ; layer of retina; ; neural layer of retina; ; bone marrow; ; primary visual cortex; ; superior frontal gyrus; ; striatum of neuraxis; ; hippocampus proper; ; olfactory bulb; ; Hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	C-C chemokine binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; chemokine binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; recycling endosome; endosome; plasma membrane; early endosome; membrane;
Biological process	chemokine-mediated signaling pathway; regulation of chemokine production; G protein-coupled receptor signaling pathway; defense response; inflammatory response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2532
	13349
	ENSG00000213088
	ENSMUSG00000037872
	Q16570
	Q9QUI6
	NM_002036; NM_001122951
	NM_010045
	NP_001116423; NP_002027
	NP_034175
	Wikidata
View/Edit Human	View/Edit Mouse

Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene.

The Duffy antigen is located on the surface of red blood cells, and is named after the patient in whom it was discovered. The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The protein is also the receptor for the human malarial parasites Plasmodium vivax, Plasmodium knowlesi and simian malarial parasite Plasmodium cynomolgi. Polymorphisms in this gene are the basis of the Duffy blood group system.