CD300LF

CD300LF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NMS
Identifiers
Aliases	CD300LF, CD300f, CLM-1, CLM1, IREM-1, IREM1, IgSF13, LMIR3, NKIR, CD300 molecule like family member f
External IDs	OMIM: 609807; MGI: 2442359; HomoloGene: 51396; GeneCards: CD300LF; OMA:CD300LF - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,712,978 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,024,818 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; testicle; ; spleen; ; bone marrow; ; appendix; ; bone marrow cells; ; trabecular bone; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; secondary oocyte; ; tibiofemoral joint; ; zygote; ; blood; ; primary oocyte; ; spleen; ; mesenteric lymph nodes; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylserine binding; interleukin-4 receptor binding; ceramide binding; lipid binding;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	immune system process; regulation of immune response; negative regulation of mast cell activation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; interleukin-13-mediated signaling pathway; positive regulation of interleukin-4-mediated signaling pathway; negative regulation of apoptotic cell clearance; positive regulation of apoptotic cell clearance;
	Sources:Amigo / QuickGO
Orthologs
	146722
	246746
	ENSG00000186074
	ENSMUSG00000047798
	Q8TDQ1
	Q6SJQ7
NM_001289082; NM_001289083; NM_001289084; NM_001289085; NM_001289086;
	NM_001289087; NM_139018
	NM_001169153; NM_145634; NM_001347648
NP_001276011; NP_001276012; NP_001276013; NP_001276014; NP_001276015;
	NP_001276016; NP_620587
	NP_001162624; NP_001334577; NP_663609
	Wikidata
View/Edit Human	View/Edit Mouse

CMRF35-like molecule 1, also known as CD300lf, is a protein that in humans is encoded by the CD300LF gene. CD300lf belongs to the protein family of CD300. CD300lf is a membrane glycoprotein that contains an immunoglobulin domain and is expressed by myeloid and mast cells of humans and other mammals. The protein functions in immunoregulation but might also have a role in norovirus infections.