CD32

Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
	Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).
Identifiers
Symbol	FCGR2B
Alt. symbols	FCG2, FCGR2
NCBI gene	2213
HGNC	3618
OMIM	604590
RefSeq	NM_004001
UniProt	P31994
Other data
Locus	Chr. 1 q23
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol	FCGR2A
Alt. symbols	FCG2, FCGR2A1, FCGR2
NCBI gene	2212
HGNC	3616
OMIM	146790
RefSeq	NM_021642
UniProt	P12318
Other data
Locus	Chr. 1 q23
Structures
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Structures	Swiss-model
Domains	InterPro

Fc fragment of IgG, low affinity IIc, receptor for (CD32)

Identifiers

Symbol

FCGR2C

Other data

Chr. 1 q23

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Structures	Swiss-model
Domains	InterPro

CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes. Cellular responses regulated by CD32 include phagocytosis, cytokine stimulation, and endocytic transport. Dysregulated CD32 is associated with different forms of autoimmunity, including systemic lupus erythematosus. In humans, there are three major CD32 subtypes: CD32A, CD32B, and CD32C. While CD32A and CD32C are involved in activating cellular responses, CD32B is inhibitory.