CD33

CD33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IHB, 5J06, 5J0B, 6D48, 6D49, 6D4A, 6TL8, 7AW6
Identifiers
Aliases	CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67
External IDs	OMIM: 159590; MGI: 99440; HomoloGene: 88651; GeneCards: CD33; OMA:CD33 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,243,860 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,193,852 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; blood; ; bone marrow cells; ; right coronary artery; ; upper lobe of left lung; ; right lung; ; appendix; ; right adrenal cortex;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; blood; ; tibiofemoral joint; ; gastrula; ; submandibular gland; ; calvaria; ; spleen; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; carbohydrate binding; signaling receptor activity; protein phosphatase binding; sialic acid binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; external side of plasma membrane; nucleus; plasma membrane; specific granule membrane; tertiary granule membrane; peroxisome; Golgi apparatus;
Biological process	cell-cell signaling; cell adhesion; signal transduction; negative regulation of cell population proliferation; regulation of immune response; neutrophil degranulation; immune response-inhibiting signal transduction; positive regulation of protein secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-8 production; negative regulation of tumor necrosis factor production; negative regulation of calcium ion transport; cell-cell adhesion; positive regulation of protein tyrosine phosphatase activity; negative regulation of monocyte activation;
	Sources:Amigo / QuickGO
Orthologs
	945
	12489
	ENSG00000105383
	ENSMUSG00000004609
	P20138
	Q63994
	NM_001082618; NM_001177608; NM_001772
	NM_001111058; NM_021293
	NP_001076087; NP_001171079; NP_001763
	NP_001104528; NP_067268
	Wikidata
View/Edit Human	View/Edit Mouse

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.