CD40 (protein)

CD40
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI
Identifiers
Aliases	CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
External IDs	OMIM: 109535; MGI: 88336; HomoloGene: 954; GeneCards: CD40; OMA:CD40 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,129,863 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,914,868 bp
RNA expression pattern
	Top expressed in
	lymph node; ; right lung; ; spleen; ; upper lobe of left lung; ; left ovary; ; Descending thoracic aorta; ; right ovary; ; appendix; ; gastric mucosa; ; ascending aorta;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; tail of embryo; ; blood; ; external carotid artery; ; internal carotid artery; ; semi-lunar valve; ; thymus; ; ascending aorta; ; vas deferens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	antigen binding; signal transducer activity; protein binding; tumor necrosis factor-activated receptor activity; enzyme binding; ubiquitin protein ligase binding; protein domain specific binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; CD40 receptor complex; extracellular exosome; external side of plasma membrane; extracellular space; soma; varicosity;
Biological process	positive regulation of protein phosphorylation; positive regulation of MAP kinase activity; positive regulation of interleukin-12 production; protein kinase B signaling; positive regulation of protein kinase C signaling; immune system process; cellular calcium ion homeostasis; tumor necrosis factor-mediated signaling pathway; immune response-regulating cell surface receptor signaling pathway; platelet activation; multicellular organism development; B cell activation; positive regulation of GTPase activity; response to lipopolysaccharide; B cell proliferation; cellular response to mechanical stimulus; positive regulation of endothelial cell apoptotic process; regulation of cell population proliferation; positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; defense response to virus; immune response; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; apoptotic signaling pathway; positive regulation of isotype switching to IgG isotypes; cellular response to lipopolysaccharide; positive regulation of transcription by RNA polymerase II; defense response to protozoan; response to bacterium; response to nutrient levels; response to cobalamin; response to interferon-gamma; cellular response to erythropoietin; cellular response to interleukin-1; cellular response to tumor necrosis factor; response to peptide; inflammatory response; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	958
	21939
	ENSG00000101017
	ENSMUSG00000017652
	P25942
	P27512
NM_001250; NM_001302753; NM_152854; NM_001322421; NM_001322422;
	NM_001362758
	NM_011611; NM_170702; NM_170703; NM_170704
NP_001241; NP_001289682; NP_001309350; NP_001309351; NP_690593;
	NP_001349687
	NP_035741; NP_733803; NP_733804; NP_733805
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T_H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

Activated CD4+ T cells primarily exhibit its ligand CD40L/CD154 to antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells.

Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.