Integrin alpha 5

ITGA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4
Identifiers
Aliases	ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5
External IDs	OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA:ITGA5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,419,266 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,275,190 bp
RNA expression pattern
	Top expressed in
	tibial arteries; ; saphenous vein; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; stromal cell of endometrium; ; ascending aorta; ; smooth muscle tissue; ; left uterine tube; ; upper lobe of left lung; ; right lung;
	Top expressed in
	tail of embryo; ; decidua; ; ascending aorta; ; aortic valve; ; gastrula; ; stroma of bone marrow; ; yolk sac; ; genital tubercle; ; atrium; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor receptor 2 binding; virus receptor activity; epidermal growth factor receptor binding; metal ion binding; platelet-derived growth factor receptor binding; integrin binding; protein binding; cell adhesion molecule binding;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; alphav-beta3 integrin-vitronectin complex; membrane; cell-cell junction; ruffle; plasma membrane; synapse; ruffle membrane; cell surface; integrin complex; endoplasmic reticulum; cytoplasmic vesicle; external side of plasma membrane; focal adhesion; cell junction;
Biological process	leukocyte cell-cell adhesion; positive regulation of vascular endothelial growth factor receptor signaling pathway; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; endodermal cell differentiation; positive regulation of cell migration; heterotypic cell-cell adhesion; wound healing, spreading of epidermal cells; extracellular matrix organization; memory; cell-cell adhesion mediated by integrin; positive regulation of sprouting angiogenesis; cell-substrate adhesion; cell adhesion; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell-substrate junction assembly; integrin-mediated signaling pathway; viral entry into host cell; viral process; negative regulation of anoikis; leukocyte migration; positive regulation of cell-substrate adhesion; regulation of angiogenesis; cell adhesion mediated by integrin; female pregnancy;
	Sources:Amigo / QuickGO
Orthologs
	3678
	16402
	ENSG00000161638
	ENSMUSG00000000555
	P08648
	P11688
	NM_002205
	NM_010577; NM_001314041
	NP_002196
	NP_001300970; NP_034707
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.