CD82 (gene)

CD82
Identifiers
Aliases	CD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
External IDs	OMIM: 600623; MGI: 104651; HomoloGene: 20512; GeneCards: CD82; OMA:CD82 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	44,620,358 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	93,293,485 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; beta cell; ; mucosa of esophagus; ; upper lobe of left lung; ; lymph node; ; olfactory zone of nasal mucosa; ; right lung; ; skin of abdomen; ; gallbladder; ; thoracic diaphragm;
	Top expressed in
	parotid gland; ; lacrimal gland; ; choroid plexus of fourth ventricle; ; granulocyte; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; submandibular gland; ; pyloric antrum; ; ileum; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	cell surface receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3732
	12521
	ENSG00000085117
	ENSMUSG00000027215
	P27701
	P40237
	NM_001024844; NM_002231
NM_001136055; NM_001271430; NM_001271431; NM_001271432; NM_001271461;
	NM_001271462; NM_007656
	NP_001020015; NP_002222
NP_001129527; NP_001258359; NP_001258360; NP_001258361; NP_001258390;
	NP_001258391; NP_031682
	Wikidata
View/Edit Human	View/Edit Mouse

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene.

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.