LRP1

LRP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY
Identifiers
Aliases	LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R
External IDs	OMIM: 107770; MGI: 96828; HomoloGene: 1744; GeneCards: LRP1; OMA:LRP1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,213,361 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,457,017 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Descending thoracic aorta; ; ascending aorta; ; right ovary; ; left ovary; ; right coronary artery; ; tibial nerve; ; canal of the cervix; ; sural nerve; ; left coronary artery;
	Top expressed in
	stroma of bone marrow; ; superior frontal gyrus; ; internal carotid artery; ; external carotid artery; ; ankle; ; primary visual cortex; ; lip; ; choroid plexus of fourth ventricle; ; cerebellar cortex; ; perirhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; apolipoprotein binding; lipoprotein particle receptor binding; protein-containing complex binding; metal ion binding; protease binding; protein binding; low-density lipoprotein particle receptor activity; RNA binding; amyloid-beta binding; scavenger receptor activity; coreceptor activity; alpha-2 macroglobulin receptor activity; apolipoprotein receptor activity; clathrin heavy chain binding; signaling receptor activity; cargo receptor activity; heparan sulfate proteoglycan binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; endosome; membrane; focal adhesion; receptor complex; plasma membrane; integral component of plasma membrane; lysosomal membrane; soma; dendrite; nucleolus; clathrin-coated pit; clathrin-coated vesicle; nucleus; cytoplasm; cytosol; early endosome; basolateral plasma membrane; insulin-responsive compartment; axonal growth cone; apical part of cell; plasma membrane protein complex;
Biological process	lipoprotein metabolic process; negative regulation of neuron apoptotic process; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of neuron projection development; endocytosis; regulation of actin cytoskeleton organization; regulation of phospholipase A2 activity; amyloid-beta clearance; negative regulation of Wnt signaling pathway; ageing; negative regulation of smooth muscle cell migration; positive regulation of lipid transport; receptor-mediated endocytosis; aorta morphogenesis; retinoid metabolic process; regulation of cholesterol transport; positive regulation of protein transport; apoptotic cell clearance; multicellular organism development; protein kinase C-activating G protein-coupled receptor signaling pathway; positive regulation of cholesterol efflux; cerebral cortex development; cell population proliferation; lipoprotein transport; regulation of extracellular matrix disassembly; astrocyte activation involved in immune response; lipid metabolism; phagocytosis; positive regulation of cytosolic calcium ion concentration; negative regulation of cell-substrate adhesion; positive regulation of cell death; positive regulation of neuron projection development; receptor internalization; positive regulation of protein binding; positive regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of apoptotic process; cellular lipid catabolic process; transcytosis; positive regulation of axon extension; positive regulation of endocytosis; positive regulation of axon extension involved in regeneration; positive regulation of collateral sprouting of injured axon; positive regulation of phagocytosis; negative regulation of cytosolic calcium ion concentration; negative regulation of focal adhesion assembly; negative regulation of cell death; chemoattraction of axon; positive regulation of ERK1 and ERK2 cascade; amyloid-beta clearance by transcytosis; amyloid-beta clearance by cellular catabolic process; positive regulation of Schwann cell migration; positive regulation of amyloid-beta clearance; positive regulation of protein localization to plasma membrane; positive regulation of cholesterol import; cellular response to amyloid-beta; positive regulation of vascular associated smooth muscle cell migration; positive regulation of lysosomal protein catabolic process; lysosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	4035
	16971
	ENSG00000123384
	ENSMUSG00000040249
	Q07954
	Q91ZX7
	NM_002332
	NM_008512
	NP_002323
	NP_032538
	Wikidata
View/Edit Human	View/Edit Mouse

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.