CD97

ADGRE5
Identifiers
Aliases	ADGRE5, TM7LN1, CD97, adhesion G protein-coupled receptor E5
External IDs	OMIM: 601211; MGI: 1347095; HomoloGene: 8050; GeneCards: ADGRE5; OMA:ADGRE5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,408,725 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,467,955 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; ascending aorta; ; blood; ; Descending thoracic aorta; ; body of uterus; ; spleen; ; right coronary artery; ; upper lobe of left lung; ; stromal cell of endometrium;
	Top expressed in
	granulocyte; ; thymus; ; urinary bladder; ; esophagus; ; proximal tubule; ; lung; ; jejunum; ; smooth muscle tissue; ; spleen; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; focal adhesion; extracellular space; secretory granule membrane;
Biological process	cell-cell signaling; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell adhesion; inflammatory response; immune response; signal transduction; neutrophil degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	976
	26364
	ENSG00000123146
	ENSMUSG00000002885
	P48960
	Q9Z0M6
	NM_001025160; NM_001784; NM_078481
	NM_001163029; NM_001163030; NM_001163031; NM_011925
	NP_001020331; NP_001775; NP_510966
	NP_001156501; NP_001156502; NP_001156503; NP_036055
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene. CD97 is a member of the adhesion G protein-coupled receptor (GPCR) family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

CD97 is widely expressed on, among others, hematopoietic stem and progenitor cells, immune cells, epithelial cells, muscle cells as well as their malignant counterparts. In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. Alternative splicing has been observed for this gene and three variants have been found. The N-terminal fragment of CD97 contains 3-5 EGF-like domains in human and 3-4 EGF-like domains in mice.