CDC14A

CDC14A
Identifiers
Aliases	CDC14A, cdc14, hCDC14, cell division cycle 14A, DFNB105, DFNB35, DFNB32
External IDs	OMIM: 603504; MGI: 2442676; HomoloGene: 75343; GeneCards: CDC14A; OMA:CDC14A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,520,277 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	116,428,745 bp
RNA expression pattern
	Top expressed in
	sperm; ; buccal mucosa cell; ; mucosa of paranasal sinus; ; right uterine tube; ; right testis; ; left testis; ; glomerulus; ; metanephric glomerulus; ; olfactory zone of nasal mucosa; ; Achilles tendon;
	Top expressed in
	ciliary body; ; iris; ; retinal pigment epithelium; ; otolith organ; ; utricle; ; spermatid; ; vestibular sensory epithelium; ; olfactory epithelium; ; intercostal muscle; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	centrosome; spindle; nucleoplasm; microtubule organizing center; mitotic spindle; cytoskeleton; nucleus; spindle pole; cytoplasm; cytosol; nuclear body; cell projection; kinocilium; stereocilium tip; kinociliary basal body; nucleolus; stereocilium;
Biological process	mitotic spindle midzone assembly; protein dephosphorylation; cell division; cell cycle; cell population proliferation; dephosphorylation; peptidyl-tyrosine dephosphorylation; regulation of exit from mitosis; cilium assembly; hearing; microtubule cytoskeleton organization; mitotic cell cycle; positive regulation of cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	8556
	229776
	ENSG00000079335
	ENSMUSG00000033502
	Q9UNH5
	Q6GQT0
NM_003672; NM_033312; NM_033313; NM_001319210; NM_001319211;
	NM_001319212
	NM_001080818; NM_001173553; NM_001355646; NM_001378993; NM_001378994
NP_001306139; NP_001306140; NP_001306141; NP_003663; NP_201569;
	NP_201570
	NP_001074287; NP_001167024; NP_001342575; NP_001365922; NP_001365923
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.