CDC14B

CDC14B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OHC, 1OHD, 1OHE
Identifiers
Aliases	CDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDs	OMIM: 603505; MGI: 2441808; HomoloGene: 104197; GeneCards: CDC14B; OMA:CDC14B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	96,619,843 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	64,275,290 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; tendon of biceps brachii; ; internal globus pallidus; ; optic nerve; ; retinal pigment epithelium; ; C1 segment; ; gonad; ; inferior ganglion of vagus nerve; ; bronchial epithelial cell; ; seminal vesicula;
	Top expressed in
	hand; ; Epithelium of choroid plexus; ; spermatid; ; primitive streak; ; gastrula; ; maxillary prominence; ; left lobe of liver; ; mandibular prominence; ; tail of embryo; ; atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; phosphatase activity; protein binding; protein serine/threonine phosphatase activity;
Cellular component	nucleus; nucleolus; cytoplasm; nucleoplasm; spindle pole; centrosome; mitotic spindle;
Biological process	DNA repair; cellular response to DNA damage stimulus; dephosphorylation; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of ubiquitin protein ligase activity; regulation of exit from mitosis; mitotic spindle midzone assembly; cilium assembly; mitotic G2 DNA damage checkpoint signaling; microtubule cytoskeleton organization; mitotic cell cycle; positive regulation of cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	8555
	218294
	ENSG00000081377
	ENSMUSG00000033102
	O60729
	Q6PFY9
NM_001077181; NM_003671; NM_033331; NM_033332; NM_001351567;
	NM_001351568; NM_001351569; NM_001351570
	NM_001122989; NM_172587
NP_001070649; NP_003662; NP_201588; NP_001338496; NP_001338497;
	NP_001338498; NP_001338499
	NP_001116461; NP_766175
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.