CDC25B

CDC25B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU, 4WH7, 4WH9
Identifiers
Aliases	CDC25B, cell division cycle 25B
External IDs	OMIM: 116949; MGI: 99701; HomoloGene: 41451; GeneCards: CDC25B; OMA:CDC25B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,806,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	131,040,417 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lung; ; right hemisphere of cerebellum; ; gastric mucosa; ; upper lobe of left lung; ; oocyte; ; stromal cell of endometrium; ; secondary oocyte; ; lymph node; ; anterior pituitary;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; blood; ; tibiofemoral joint; ; ventricular zone; ; lip; ; human fetus; ; spleen; ; thymus; ; granulocyte; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tyrosine phosphatase activity; hydrolase activity; protein kinase binding; phosphoprotein phosphatase activity;
Cellular component	cytosol; centrosome; spindle pole; intracellular anatomical structure; microtubule organizing center; cytoskeleton; nucleus; nucleoplasm; cytoplasm;
Biological process	protein dephosphorylation; positive regulation of mitotic cell cycle; cell division; positive regulation of cytokinesis; protein phosphorylation; G2/M transition of mitotic cell cycle; oocyte maturation; positive regulation of cell population proliferation; cell cycle; female meiosis I; positive regulation of protein kinase activity; peptidyl-tyrosine dephosphorylation; positive regulation of cell cycle G2/M phase transition; mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	994
	12531
	ENSG00000101224
	ENSMUSG00000027330
	P30305
	P30306
NM_001287516; NM_001287517; NM_001287518; NM_001287519; NM_001287520;
	NM_001287522; NM_001287524; NM_004358; NM_021872; NM_021873; NM_021874; NM_212530
	NM_001111075; NM_023117
NP_001274445; NP_001274446; NP_001274447; NP_001274448; NP_001274449;
	NP_001274451; NP_001274453; NP_004349; NP_068658; NP_068659
	NP_001104545; NP_075606
	Wikidata
View/Edit Human	View/Edit Mouse

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.