CDC25C

CDC25C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OJX, 3BZI, 3OP3
Identifiers
Aliases	CDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDs	OMIM: 157680; MGI: 88350; HomoloGene: 1356; GeneCards: CDC25C; OMA:CDC25C - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,338,355 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,884,586 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; oocyte; ; testicle; ; secondary oocyte; ; left testis; ; ganglionic eminence; ; right testis; ; sperm; ; mucosa of transverse colon;
	Top expressed in
	membrana granulosa of ovarian follicle; ; ventricular zone; ; condyle; ; genital tubercle; ; fossa; ; tail of embryo; ; spermatid; ; primitive streak; ; epiblast; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; WW domain binding; protein tyrosine phosphatase activity; hydrolase activity; protein kinase binding; phosphoprotein phosphatase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; nucleoplasm; perinuclear region of cytoplasm; nucleus; nuclear speck;
Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell cycle; cell division; DNA replication; G2/M transition of mitotic cell cycle; spermatogenesis; cell cycle; cell population proliferation; viral process; regulation of mitotic nuclear division; peptidyl-tyrosine dephosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of cell cycle G2/M phase transition; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	995
	12532
	ENSG00000158402
	ENSMUSG00000044201
	P30307
	P48967
NM_001287582; NM_001287583; NM_001790; NM_022809; NM_001318098;
	NM_001364026; NM_001364027; NM_001364028
	NM_009860
NP_001274511; NP_001274512; NP_001305027; NP_001781; NP_073720;
	NP_001350955; NP_001350956; NP_001350957
	NP_033990
	Wikidata
View/Edit Human	View/Edit Mouse

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.