CDC34

CDC34
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OB4, 3RZ3, 4MDK
Identifiers
Aliases	CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDs	OMIM: 116948; MGI: 102657; HomoloGene: 55815; GeneCards: CDC34; OMA:CDC34 - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 19 (human)
End	542,092 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,524,232 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; apex of heart; ; ventricular zone; ; right hemisphere of cerebellum; ; muscle layer of sigmoid colon; ; muscle of thigh; ; ganglionic eminence; ; right lobe of liver; ; gastrocnemius muscle;
	Top expressed in
	quadriceps femoris muscle; ; muscle of thigh; ; muscle tissue; ; skeletal muscle tissue; ; epiblast; ; testicle; ; placenta; ; lip; ; white adipose tissue; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol; nuclear speck;
Biological process	negative regulation of cAMP-mediated signaling; cellular response to interferon-beta; protein polyubiquitination; positive regulation of inclusion body assembly; protein K48-linked ubiquitination; positive regulation of neuron apoptotic process; DNA replication initiation; cell cycle; response to growth factor; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; G1/S transition of mitotic cell cycle; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	997
	216150
	ENSG00000099804
	ENSMUSG00000020307
	P49427
	Q8CFI2
	NM_004359
	NM_177613; NM_001359817; NM_001359818
	NP_004350
	NP_808281; NP_001346746; NP_001346747
	Wikidata
View/Edit Human	View/Edit Mouse

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.

CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle. Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1 - for ubiquitin-mediated protein degradation. CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.