CDC42EP3

CDC42EP3
Identifiers
Aliases	CDC42EP3, BORG2, CEP3, UB1, CDC42 effector protein 3
External IDs	OMIM: 606133; MGI: 2384718; HomoloGene: 4708; GeneCards: CDC42EP3; OMA:CDC42EP3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	37,738,468 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,662,520 bp
RNA expression pattern
	Top expressed in
	tibia; ; monocyte; ; seminal vesicula; ; myocardium of left ventricle; ; glomerulus; ; metanephric glomerulus; ; saphenous vein; ; right ventricle; ; tail of epididymis; ; myometrium;
	Top expressed in
	spermatocyte; ; condyle; ; tibiofemoral joint; ; tunica media of zone of aorta; ; granulocyte; ; vas deferens; ; urinary bladder; ; seminiferous tubule; ; calvaria; ; ascending aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; cytoskeletal regulatory protein binding; protein binding;
Cellular component	cytoplasm; cytosol; cytoskeleton; membrane; endomembrane system; actin cytoskeleton; plasma membrane;
Biological process	positive regulation of pseudopodium assembly; positive regulation of actin filament polymerization; Rho protein signal transduction; signal transduction; regulation of cell shape; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	10602
	260409
	ENSG00000163171
	ENSMUSG00000036533
	Q9UKI2
	Q9CQC5
NM_001270436; NM_001270437; NM_001270438; NM_006449; NM_001371569;
	NM_001371570
	NM_026514
NP_001257365; NP_001257366; NP_001257367; NP_006440; NP_001358498;
	NP_001358499
	NP_080790
	Wikidata
View/Edit Human	View/Edit Mouse

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.