Cadherin-2

CDH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ
Identifiers
Aliases	CDH2, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
External IDs	OMIM: 114020; MGI: 88355; HomoloGene: 20424; GeneCards: CDH2; OMA:CDH2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	28,177,946 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	16,942,303 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; ventricular zone; ; stromal cell of endometrium; ; myocardium; ; myocardium of left ventricle; ; endothelial cell; ; ganglionic eminence; ; cardiac muscle tissue of right atrium; ; Brodmann area 23; ; middle temporal gyrus;
	Top expressed in
	median eminence; ; atrium; ; lateral septal nucleus; ; myocardium of ventricle; ; ventromedial nucleus; ; lateral geniculate nucleus; ; cardiac muscle tissue of left ventricle; ; dorsomedial hypothalamic nucleus; ; mammillary body; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; gamma-catenin binding; metal ion binding; protein binding; enzyme binding; protein phosphatase binding; alpha-catenin binding; protein kinase binding; beta-catenin binding; identical protein binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	cytoplasm; integral component of membrane; membrane; intercalated disc; cell-cell junction; focal adhesion; plasma membrane raft; adherens junction; plasma membrane; synapse; basolateral plasma membrane; apical plasma membrane; cortical actin cytoskeleton; catenin complex; fascia adherens; extracellular exosome; lamellipodium; postsynaptic density; sarcolemma; endoplasmic reticulum lumen; cell surface; cell junction; extracellular matrix; integral component of plasma membrane; neuron projection; apical part of cell; collagen-containing extracellular matrix; integral component of presynaptic active zone membrane; integral component of postsynaptic specialization membrane;
Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; blood vessel morphogenesis; homeostasis of number of cells; positive regulation of muscle cell differentiation; regulation of postsynaptic density protein 95 clustering; glial cell differentiation; neuroepithelial cell differentiation; cell-cell adhesion mediated by cadherin; radial glial cell differentiation; neuronal stem cell population maintenance; regulation of oligodendrocyte progenitor proliferation; telencephalon development; neuroligin clustering involved in postsynaptic membrane assembly; positive regulation of synaptic vesicle clustering; cell adhesion; regulation of signal transduction; cerebral cortex development; striated muscle cell differentiation; adherens junction organization; cell migration; negative regulation of canonical Wnt signaling pathway; positive regulation of MAPK cascade; homophilic cell adhesion via plasma membrane adhesion molecules; brain morphogenesis; post-translational protein modification; protein localization to plasma membrane; cell morphogenesis; cell-cell junction assembly; synapse assembly; regulation of axonogenesis; regulation of synaptic transmission, glutamatergic; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1000
	12558
	ENSG00000170558
	ENSMUSG00000024304
	P19022
	P15116
	NM_001308176; NM_001792
	NM_007664
	NP_001295105; NP_001783; NP_001783.2
	NP_031690
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.