CDH4

CDH4
Identifiers
Aliases	CDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDs	OMIM: 603006; MGI: 99218; HomoloGene: 48044; GeneCards: CDH4; OMA:CDH4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	61,940,617 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,541,166 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; nucleus accumbens; ; temporal lobe; ; Amygdala; ; caudate nucleus; ; anterior cingulate cortex; ; putamen; ; testicle; ; prefrontal cortex;
	Top expressed in
	Bowman's capsule; ; saccule; ; anterior amygdaloid area; ; coelomic epithelium; ; epithelium of lens; ; glomerulus; ; gastrula; ; olfactory bulb; ; ganglionic eminence; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell surface; catenin complex;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; positive regulation of axon extension; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; cell-cell junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell-cell adhesion; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1002
	12561
	ENSG00000280641; ENSG00000179242
	ENSMUSG00000000305
	P55283
	P39038
	NM_001794; NM_001252338; NM_001252339
	NM_009867; NM_001316723
	NP_001239267; NP_001239268; NP_001785
	NP_001303652; NP_033997
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.