CDIPT

CDIPT
Identifiers
Aliases	CDIPT, PIS, PIS1, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
External IDs	OMIM: 605893; MGI: 105491; HomoloGene: 7159; GeneCards: CDIPT; OMA:CDIPT - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,863,414 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,579,673 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; endothelial cell; ; Brodmann area 23; ; sperm; ; middle temporal gyrus; ; pancreatic ductal cell; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; gingival epithelium;
	Top expressed in
	Paneth cell; ; motor neuron; ; substantia nigra; ; retinal pigment epithelium; ; barrel cortex; ; seminal vesicula; ; endocardial cushion; ; fossa; ; facial motor nucleus; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphotransferase activity, for other substituted phosphate groups; manganese ion binding; alcohol binding; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; protein binding; diacylglycerol binding; carbohydrate binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; endoplasmic reticulum;
Biological process	lipid metabolism; CDP-diacylglycerol metabolic process; phospholipid biosynthetic process; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10423
	52858
	ENSG00000103502
	ENSMUSG00000030682
	O14735
	Q8VDP6
	NM_001286585; NM_001286586; NM_006319; NM_145752
	NM_026638; NM_001347656; NM_001379260
NP_001273514; NP_001273515; NP_006310; NP_001273514.1; NP_001273515.1;
	NP_006310.1
	NP_001334585; NP_080914; NP_001366189
	Wikidata
View/Edit Human	View/Edit Mouse

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.