CDK5R2

CDK5R2
Identifiers
Aliases	CDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDs	OMIM: 603764; MGI: 1330828; HomoloGene: 2924; GeneCards: CDK5R2; OMA:CDK5R2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,962,155 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,896,891 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; right frontal lobe; ; putamen; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; lateral nuclear group of thalamus; ; caudate nucleus; ; pituitary gland;
	Top expressed in
	superior frontal gyrus; ; neural layer of retina; ; supraoptic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; prefrontal cortex; ; cerebellar cortex; ; lateral septal nucleus; ; olfactory tubercle; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase activator activity; lipid binding; actin binding;
Cellular component	cytoplasm; protein kinase 5 complex; plasma membrane; membrane; growth cone; neuron projection;
Biological process	positive regulation of protein kinase activity; regulation of cyclin-dependent protein serine/threonine kinase activity; neuron migration; hippocampus development; layer formation in cerebral cortex; cerebellum development; positive regulation of protein serine/threonine kinase activity; superior olivary nucleus maturation; positive regulation of calcium ion-dependent exocytosis; positive regulation of cyclin-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8941
	12570
	ENSG00000171450
	ENSMUSG00000090071
	Q13319
	O35926
	NM_003936
	NM_009872
	NP_003927
	NP_034002
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.