CDK5RAP1

CDK5RAP1
Identifiers
Aliases	CDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1
External IDs	OMIM: 608200; MGI: 1914221; HomoloGene: 9502; GeneCards: CDK5RAP1; OMA:CDK5RAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,401,561 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,214,930 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lobe of thyroid gland; ; apex of heart; ; left lobe of thyroid gland; ; skin of leg; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; skin of abdomen; ; gonad; ; spleen;
	Top expressed in
	primary oocyte; ; muscle of thigh; ; right kidney; ; proximal tubule; ; morula; ; thoracic diaphragm; ; spermatocyte; ; skeletal muscle tissue; ; blastocyst; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; transferase activity; iron-sulfur cluster binding; catalytic activity; protein kinase binding; metal ion binding; N6-isopentenyladenosine methylthiotransferase activity; 4 iron, 4 sulfur cluster binding;
Cellular component	cytoplasm; mitochondrion; cellular component;
Biological process	regulation of neuron differentiation; brain development; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; tRNA modification; positive regulation of mitochondrial translation; mitochondrial tRNA modification; positive regulation of translational fidelity; tRNA methylthiolation; RNA modification;
	Sources:Amigo / QuickGO
Orthologs
	51654
	66971
	ENSG00000101391
	ENSMUSG00000027487
	Q96SZ6
	Q8BTW8
NM_001278167; NM_001278168; NM_001278169; NM_016082; NM_016408;
	NM_001365728
	NM_025876
NP_001265096; NP_001265097; NP_001265098; NP_057166; NP_057492;
	NP_001352657
	NP_080152
	Wikidata
View/Edit Human	View/Edit Mouse

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.