Cyclin-dependent kinase 7

CDK7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UA2
Identifiers
Aliases	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
External IDs	OMIM: 601955; MGI: 102956; HomoloGene: 1363; GeneCards: CDK7; OMA:CDK7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	69,277,430 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	100,867,447 bp
RNA expression pattern
	Top expressed in
	placenta; ; gonad; ; islet of Langerhans; ; testicle; ; left testis; ; olfactory zone of nasal mucosa; ; right testis; ; stromal cell of endometrium; ; zone of skin; ; skin of leg;
	Top expressed in
	otic placode; ; primitive streak; ; abdominal wall; ; renal corpuscle; ; calvaria; ; endocardial cushion; ; morula; ; vas deferens; ; yolk sac; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; ATP-dependent activity, acting on DNA; transcription coactivator activity; protein C-terminus binding; protein binding; androgen receptor binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	nucleoplasm; perinuclear region of cytoplasm; nucleus; cytoplasm; cyclin-dependent protein kinase activating kinase holoenzyme complex; transcription factor TFIIH holo complex; transcription factor TFIIK complex;
Biological process	termination of RNA polymerase I transcription; androgen receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-templated; phosphorylation; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; cell division; positive regulation of transcription, DNA-templated; protein phosphorylation; cell cycle; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; cell population proliferation; positive regulation of transcription by RNA polymerase II; snRNA transcription by RNA polymerase II; nucleotide-excision repair, preincision complex assembly; DNA repair; protein stabilization; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	1022
	12572
	ENSG00000134058; ENSG00000277273
	ENSMUSG00000069089
	P50613
	Q03147
NM_001799; NM_001324069; NM_001324070; NM_001324071; NM_001324072;
	NM_001324074; NM_001324075; NM_001324077; NM_001324078
	NM_009874
NP_001310998; NP_001310999; NP_001311000; NP_001311001; NP_001311003;
	NP_001311004; NP_001311006; NP_001311007; NP_001790
	NP_034004
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression.

This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.