Cyclin-dependent kinase 8

CDK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBH, 5CEI, 5FGK, 5HBE, 5BNJ, 5HBJ, 5HVY, 5HNB, 5I5Z
Identifiers
Aliases	CDK8, K35, cyclin-dependent kinase 8, cyclin dependent kinase 8, IDDHBA
External IDs	OMIM: 603184; MGI: 1196224; HomoloGene: 55565; GeneCards: CDK8; OMA:CDK8 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,405,238 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,239,684 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; sperm; ; parietal pleura; ; endothelial cell; ; muscle layer of sigmoid colon; ; visceral pleura; ; amniotic fluid; ; jejunal mucosa; ; ganglionic eminence;
	Top expressed in
	ureter; ; secondary oocyte; ; primitive streak; ; zygote; ; medullary collecting duct; ; mandibular prominence; ; Paneth cell; ; somite; ; vestibular sensory epithelium; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	mediator complex; nucleoplasm; nucleus; nucleolus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; phosphorylation; protein phosphorylation; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of mitotic cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1024
	264064
	ENSG00000132964
	ENSMUSG00000029635
	P49336
	Q8R3L8
	NM_001260; NM_001318368; NM_001346501
	NM_153599; NM_181570; NM_001359990; NM_001359991
	NP_001251; NP_001305297; NP_001333430
	NP_705827; NP_001346919; NP_001346920
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.