CDKAL1

CDKAL1
Identifiers
Aliases	CDKAL1, CDK5 regulatory subunit associated protein 1 like 1
External IDs	OMIM: 611259; MGI: 1921765; HomoloGene: 9830; GeneCards: CDKAL1; OMA:CDKAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	21,232,404 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,039,657 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; ganglionic eminence; ; ventricular zone; ; testicle; ; gonad; ; muscle of thigh; ; gastrocnemius muscle; ; epithelium of colon; ; stromal cell of endometrium;
	Top expressed in
	spermatocyte; ; ascending aorta; ; spermatid; ; aortic valve; ; muscle of thigh; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; zygote; ; seminiferous tubule; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; N6-threonylcarbomyladenosine methylthiotransferase activity; iron-sulfur cluster binding; metal ion binding; protein binding; catalytic activity; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase; 4 iron, 4 sulfur cluster binding;
Cellular component	integral component of membrane; rough endoplasmic reticulum; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	maintenance of translational fidelity; tRNA methylthiolation; tRNA processing; tRNA modification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	54901
	68916
	ENSG00000145996
	ENSMUSG00000006191
	Q5VV42
	Q91WE6
	NM_017774
	NM_144536; NM_001308486
	NP_060244
	NP_001295415; NP_653119
	Wikidata
View/Edit Human	View/Edit Mouse

CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of this have not been fully determined. CDKAL1 is known to code for CDK5, a regulatory subunit-associated protein 1. This protein CDK5 regulatory subunit-associated protein 1 is found broadly across tissue types including neuronal tissues and pancreatic beta cells. CDKAL1 is suspected to be involved in the CDK5/p35 pathway, in which p35 is the activator for CDK5 which regulates several neuronal functions.