CDKN2B

CDKN2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D9S
Identifiers
Aliases	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
External IDs	OMIM: 600431; MGI: 104737; HomoloGene: 55859; GeneCards: CDKN2B; OMA:CDKN2B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	22,009,305 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	89,229,276 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon; ; oral cavity; ; mucosa of transverse colon; ; rectum; ; buccal mucosa cell; ; duodenum; ; skin of hip; ; gums;
	Top expressed in
	epithelium of stomach; ; jejunum; ; left colon; ; calvaria; ; ileum; ; endothelial cell of lymphatic vessel; ; mucous cell of stomach; ; transitional epithelium of urinary bladder; ; right lung lobe; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	cellular response to extracellular stimulus; megakaryocyte differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle checkpoint signaling; spleen development; cellular response to nutrient; negative regulation of G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; cell cycle; negative regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; cellular senescence;
	Sources:Amigo / QuickGO
Orthologs
	1030
	12579
	ENSG00000147883
	ENSMUSG00000073802
	P42772
	P55271
	NM_078487; NM_004936
	NM_007670
	NP_004927; NP_511042
	NP_031696
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15^INK4b is a protein that is encoded by the CDKN2B gene in humans.