CDKN3

CDKN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FPZ, 1FQ1
Identifiers
Aliases	CDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
External IDs	OMIM: 123832; MGI: 1919641; HomoloGene: 3805; GeneCards: CDKN3; OMA:CDKN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	54,420,218 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,009,126 bp
RNA expression pattern
	Top expressed in
	left testis; ; sperm; ; right testis; ; ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; buccal mucosa cell; ; bone marrow; ; trabecular bone;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; yolk sac; ; otic vesicle; ; ventricular zone; ; medial ganglionic eminence; ; lumbar spinal ganglion; ; genital tubercle; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; perinuclear region of cytoplasm; cytoplasm; cytosol;
Biological process	cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cell population proliferation; dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1033
	72391
	ENSG00000100526
	ENSMUSG00000037628
	Q16667
	Q810P3
	NM_001130851; NM_005192; NM_001330173
	NM_028222; NM_001360041
	NP_001124323; NP_001317102; NP_005183
	NP_082498; NP_001346970
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.