Corneodesmosin

CDSN
Identifiers
Aliases	CDSN, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
External IDs	OMIM: 602593; MGI: 3505689; HomoloGene: 48005; GeneCards: CDSN; OMA:CDSN - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,120,446 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,868,077 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; testicle; ; placenta; ; gastrocnemius muscle; ; vagina; ; skeletal muscle tissue; ; tonsil; ; gallbladder; ; duodenum;
	Top expressed in
	lip; ; skin of external ear; ; esophagus; ; skin of back; ; superior surface of tongue; ; skin of abdomen; ; subcutaneous adipose tissue; ; white adipose tissue; ; cervix; ; gastrula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity;
Cellular component	extracellular region; desmosome; cell-cell junction; cornified envelope; plasma membrane;
Biological process	cell adhesion; skin morphogenesis; keratinocyte differentiation; epidermis development; cornification; corneocyte desquamation; negative regulation of cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1041
	386463
	ENSG00000204539
	ENSMUSG00000039518
	Q15517
	Q7TPC1
	NM_001264
	NM_001008424; NM_001355275
	NP_001255
	NP_001008424; NP_001342204
	Wikidata
View/Edit Human	View/Edit Mouse

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.

This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.