Homeobox protein CDX-1

CDX1
Identifiers
Aliases	CDX1, caudal type homeobox 1, Homeobox protein CDX-1
External IDs	OMIM: 600746; MGI: 88360; HomoloGene: 1366; GeneCards: CDX1; OMA:CDX1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,184,558 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,169,271 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; mucosa of ileum; ; mucosa of sigmoid colon; ; duodenum; ; gonad; ; jejunal mucosa; ; testicle; ; epithelium of colon; ; appendix;
	Top expressed in
	left colon; ; crypt of lieberkuhn of small intestine; ; ileum; ; primitive streak; ; Ileal epithelium; ; duodenum; ; Paneth cell; ; jejunum; ; embryo; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; methyl-CpG binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	animal organ morphogenesis; multicellular organism development; pattern specification process; bone morphogenesis; cell differentiation; anterior/posterior axis specification; regulation of transcription, DNA-templated; regulation of somitogenesis; positive regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1044
	12590
	ENSG00000113722
	ENSMUSG00000024619
	P47902
	P18111
	NM_001804
	NM_009880
	NP_001795
	NP_034010
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein CDX-1 is a protein in humans that is encoded by the CDX1 gene. CDX-1 is expressed in the developing endoderm and its expression persists in the intestine throughout adulthood. CDX-1 protein expression varies along the intestine, with high expression in intestinal crypts and diminishing expression along intestinal villi.