CEBPA

CEBPA
Identifiers
Aliases	CEBPA, C/EBP-alpha, CEBP, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein alpha
External IDs	OMIM: 116897; MGI: 99480; HomoloGene: 3211; GeneCards: CEBPA; OMA:CEBPA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,302,534 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	34,821,353 bp
RNA expression pattern
	Top expressed in
	nipple; ; skin of arm; ; human penis; ; skin of thigh; ; skin of abdomen; ; right lobe of liver; ; monocyte; ; adipose tissue; ; subcutaneous adipose tissue; ; vulva;
	Top expressed in
	lactiferous gland; ; brown adipose tissue; ; subcutaneous adipose tissue; ; white adipose tissue; ; lip; ; tunica adventitia of aorta; ; skin of external ear; ; stroma of bone marrow; ; right lung; ; gallbladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription coactivator activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; kinase binding; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; RNA polymerase II transcription regulator complex; nucleolus; nucleus; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	Notch signaling pathway; transcription by RNA polymerase I; myeloid cell differentiation; regulation of transcription, DNA-templated; cellular response to lithium ion; glucose homeostasis; negative regulation of cyclin-dependent protein serine/threonine kinase activity; lung development; cytokine-mediated signaling pathway; urea cycle; regulation of transcription by RNA polymerase II; cellular response to organic cyclic compound; mitochondrion organization; embryonic placenta development; cholesterol metabolic process; negative regulation of cell cycle; negative regulation of transcription by RNA polymerase II; cell maturation; generation of precursor metabolites and energy; transcription, DNA-templated; macrophage differentiation; multicellular organism development; positive regulation of transcription, DNA-templated; positive regulation of osteoblast differentiation; granulocyte differentiation; regulation of cell population proliferation; brown fat cell differentiation; lipid homeostasis; white fat cell differentiation; inner ear development; liver development; viral process; negative regulation of transcription, DNA-templated; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase III; fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; transcription by RNA polymerase II; cellular response to tumor necrosis factor; positive regulation of DNA-templated transcription, initiation; positive regulation of macrophage activation; positive regulation of inflammatory response; interleukin-6-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1050
	12606
	ENSG00000245848
	ENSMUSG00000034957
	P49715
	P53566
	NM_004364; NM_001285829; NM_001287424; NM_001287435
	NM_001287514; NM_001287515; NM_001287521; NM_001287523; NM_007678
	NP_001272758; NP_001274353; NP_001274364; NP_004355
	NP_001274443; NP_001274444; NP_001274450; NP_001274452; NP_031704
	Wikidata
View/Edit Human	View/Edit Mouse

CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page.