CEBPE

CEBPE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T92
Identifiers
Aliases	CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon, CCAAT enhancer binding protein epsilon, c/EBP epsilon
External IDs	OMIM: 600749; MGI: 103572; HomoloGene: 1367; GeneCards: CEBPE; OMA:CEBPE - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,120,256 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	54,949,631 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; trabecular bone; ; bone marrow cells; ; gonad; ; blood; ; monocyte; ; granulocyte; ; vena cava; ; spleen; ; duodenum;
	Top expressed in
	granulocyte; ; bone marrow; ; embryo; ; liver; ; jejunum; ; ileum; ; spleen; ; lip; ; quadriceps femoris muscle; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	defense response; myeloid cell differentiation; positive regulation of gene expression; cellular response to lipopolysaccharide; regulation of transcription, DNA-templated; defense response to bacterium; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; macrophage differentiation; phagocytosis; transcription by RNA polymerase II; granulocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1053
	110794
	ENSG00000092067
	ENSMUSG00000052435
	Q15744
	Q6PZD9
	NM_001805
	NM_207131
	NP_001796
	NP_997014
	Wikidata
View/Edit Human	View/Edit Mouse

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic.

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.