CELSR3

CELSR3
Identifiers
Aliases	CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDs	OMIM: 604264; MGI: 1858236; HomoloGene: 1077; GeneCards: CELSR3; OMA:CELSR3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,662,886 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,730,168 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; pituitary gland; ; paraflocculus of cerebellum; ; Brodmann area 10; ; cerebellar vermis; ; anterior pituitary; ; right frontal lobe; ; postcentral gyrus; ; Region I of hippocampus proper;
	Top expressed in
	cerebellar cortex; ; Hypothalamus; ; olfactory bulb; ; ganglionic eminence; ; primary visual cortex; ; superior frontal gyrus; ; striatum of neuraxis; ; granulocyte; ; layer of retina; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	regulation of protein phosphorylation; dopaminergic neuron axon guidance; G protein-coupled receptor signaling pathway; serotonergic neuron axon guidance; neuron migration; regulation of protein localization; multicellular organism development; Wnt signaling pathway, planar cell polarity pathway; cell surface receptor signaling pathway; cell adhesion; axonal fasciculation; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; planar cell polarity pathway involved in axon guidance; cilium assembly; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1951
	107934
	ENSG00000008300
	ENSMUSG00000023473
	Q9NYQ7
	Q91ZI0
	NM_001407
	NM_080437; NM_001359572; NM_001359573
	NP_001398
	NP_536685; NP_001346501; NP_001346502
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.