CENPA

CENPA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AN2, 3NQJ, 3NQU, 3R45, 3WTP, 5CVD
Identifiers
Aliases	CENPA, CENP-A, CenH3, centromere protein A
External IDs	OMIM: 117139; MGI: 88375; HomoloGene: 1369; GeneCards: CENPA; OMA:CENPA - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	26,801,067 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	30,832,174 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; ventricular zone; ; buccal mucosa cell; ; ganglionic eminence; ; testicle; ; thymus; ; trabecular bone; ; bone marrow;
	Top expressed in
	endocardial cushion; ; ventricular zone; ; renal corpuscle; ; medial ganglionic eminence; ; maxillary prominence; ; mandibular prominence; ; abdominal wall; ; primitive streak; ; otic placode; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; chromatin binding; protein binding; protein heterodimerization activity; nucleosomal DNA binding;
Cellular component	inner kinetochore; cytosol; nucleoplasm; chromosome; chromosome, centromeric region; nucleus; kinetochore; nucleosome;
Biological process	CENP-A containing chromatin assembly; establishment of mitotic spindle orientation; protein localization to chromosome, centromeric region; viral process; kinetochore assembly; sister chromatid cohesion; mitotic cytokinesis; cell cycle; cell division; nucleosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	1058
	12615
	ENSG00000115163
	ENSMUSG00000029177
	P49450
	O35216
	NM_001809; NM_001042426
	NM_007681; NM_001302129; NM_001302130; NM_001302131; NM_001302132
	NP_001035891; NP_001800
	NP_001289058; NP_001289059; NP_001289060; NP_001289061; NP_031707
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.