Centromere protein E

CENPE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T5C
Identifiers
Aliases	CENPE, CENP-E, KIF10, PPP1R61, MCPH13, Centromere protein E
External IDs	OMIM: 117143; MGI: 1098230; HomoloGene: 20429; GeneCards: CENPE; OMA:CENPE - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	103,198,445 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	134,979,372 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ventricular zone; ; testicle; ; secondary oocyte; ; ganglionic eminence; ; gonad; ; trabecular bone; ; bone marrow; ; stromal cell of endometrium; ; bone marrow cells;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; tail of embryo; ; maxillary prominence; ; ventricular zone; ; primary oocyte; ; mandibular prominence; ; abdominal wall; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; protein binding; microtubule motor activity; microtubule binding; kinetochore binding;
Cellular component	spindle; kinesin complex; chromosome; nucleus; outer kinetochore; chromosome, centromeric region; membrane; midbody; microtubule; kinetochore; condensed chromosome, centromeric region; microtubule cytoskeleton; mitotic spindle midzone; cytoskeleton; cytoplasm; cytosol; kinetochore microtubule; nucleoplasm; spindle midzone;
Biological process	regulation of mitotic metaphase/anaphase transition; cell cycle; positive regulation of protein kinase activity; multicellular organism development; cell division; antigen processing and presentation of exogenous peptide antigen via MHC class II; kinetochore assembly; microtubule-based movement; sister chromatid cohesion; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; metaphase plate congression; lateral attachment of mitotic spindle microtubules to kinetochore; mitotic cell cycle; mitotic spindle organization; mitotic chromosome movement towards spindle pole; microtubule plus-end directed mitotic chromosome migration; chromosome segregation; mitotic metaphase plate congression; attachment of mitotic spindle microtubules to kinetochore;
	Sources:Amigo / QuickGO
Orthologs
	1062
	229841
	ENSG00000138778
	ENSMUSG00000045328
	Q02224
	Q6RT24
	NM_001286734; NM_001813
	NM_173762
	NP_001273663; NP_001804
	NP_776123
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.

CENPE is also called Kinesin-7.