CENPO

CENPO
Identifiers
Aliases	CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	OMIM: 611504; MGI: 1923800; HomoloGene: 49760; GeneCards: CENPO; OMA:CENPO - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,822,376 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,284,294 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; testicle; ; gonad; ; secondary oocyte; ; left testis; ; right testis; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right adrenal cortex;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; otic vesicle; ; spermatocyte; ; otic placode; ; saccule; ; lumbar subsegment of spinal cord; ; Paneth cell; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; cytosol; chromosome, centromeric region; kinetochore; nucleoplasm; nucleus; Mis6-Sim4 complex;
Biological process	centromere complex assembly; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	79172
	52504
	ENSG00000138092
	ENSMUSG00000020652
	Q9BU64
	Q8K015
	NM_001199803; NM_024322; NM_001322101
	NM_134046; NM_001361641
	NP_001186732; NP_001309030; NP_077298
	NP_598807; NP_001348570
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.