CEP192

CEP192
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4N7Z
Identifiers
Aliases	CEP192, PPP1R62, centrosomal protein 192
External IDs	OMIM: 616426; MGI: 1918049; HomoloGene: 73526; GeneCards: CEP192; OMA:CEP192 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	13,125,052 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	68,018,241 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; granulocyte; ; Achilles tendon; ; testicle; ; right testis; ; left testis; ; secondary oocyte; ; mucosa of transverse colon; ; sperm;
	Top expressed in
	genital tubercle; ; tail of embryo; ; hand; ; spermatocyte; ; secondary oocyte; ; superior cervical ganglion; ; epiblast; ; zygote; ; ventricular zone; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase binding; protein binding;
Cellular component	centriole; centrosome; pericentriolar material; cytoskeleton; cytoplasm; cytosol;
Biological process	negative regulation of phosphatase activity; G2/M transition of mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; protein localization to centrosome; centrosome-templated microtubule nucleation; mitotic spindle assembly; response to bacterium; centrosome duplication; spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	55125
	70799
	ENSG00000101639
	ENSMUSG00000024542
	Q8TEP8
	n/a
	NM_018069; NM_032142
	NM_027556
	NP_115518
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.