CFAP298

CFAP298
Identifiers
Aliases	CFAP298, C21orf48, CILD26, FBB18, Kur, chromosome 21 open reading frame 59, C21orf59
External IDs	OMIM: 615494; MGI: 1915251; HomoloGene: 10941; GeneCards: CFAP298; OMA:CFAP298 - orthologs
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	90,732,002 bp
RNA expression pattern
	n/a
	Top expressed in
	zygote; ; secondary oocyte; ; neural layer of retina; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; primary oocyte; ; tail of embryo; ; muscle of thigh; ; choroidal fissure;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; cytoplasm; nucleus; cytoskeleton; cilium; cell projection;
Biological process	cell projection morphogenesis; regulation of cilium movement; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	56683
	68001
	ENSG00000159079
	ENSMUSG00000022972
	P57076
	Q8BL95
	NM_017835; NM_021254
	NM_026502
	NP_067077; NP_001337263; NP_001337264; NP_001337265; NP_001337266
	NP_080778
	Wikidata
View/Edit Human	View/Edit Mouse

Cilia- and flagella-associated protein 298 is a protein encoded by CFAP298 gene. It is of interest in part for its association with various diseases. It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype. Male Alzheimer's patients have shown a decrease in expression of CFAP298 in their blood cells. The CFAP298 gene lies within the critical region of Down Syndrome. There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae.