Cofilin 1

CFL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BEX, 1Q8G, 1Q8X, 3J0S, 5HVK, 5L6W
Identifiers
Aliases	CFL1, CFL, HEL-S-15, cofilin, cofilin 1
External IDs	OMIM: 601442; MGI: 101757; HomoloGene: 99735; GeneCards: CFL1; OMA:CFL1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,862,026 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,545,229 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; Pons; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; Brodmann area 46; ; subthalamic nucleus; ; superior vestibular nucleus; ; lateral nuclear group of thalamus; ; mucosa of colon; ; pylorus;
	Top expressed in
	Mesencephalon; ; dentate gyrus of hippocampal formation granule cell; ; neural tube; ; rhombencephalon; ; granulocyte; ; primary visual cortex; ; olfactory bulb; ; superior frontal gyrus; ; hippocampus proper; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; actin binding; actin filament binding; signaling receptor binding;
Cellular component	cytoplasm; vesicle; cell projection; membrane; focal adhesion; nuclear matrix; plasma membrane; intracellular anatomical structure; ruffle membrane; actin cytoskeleton; cytoskeleton; lamellipodium membrane; extracellular exosome; nucleus; extracellular matrix; extracellular space; cell-cell junction; cortical actin cytoskeleton; cytosol; lamellipodium;
Biological process	response to virus; negative regulation of apoptotic process; positive regulation by host of viral process; cytoskeleton organization; Rho protein signal transduction; regulation of cell morphogenesis; regulation of dendritic spine morphogenesis; actin cytoskeleton organization; actin filament depolymerization; mitotic cytokinesis; neural crest cell migration; neural fold formation; protein phosphorylation; actin filament organization; establishment of cell polarity; actin filament fragmentation; positive regulation of actin filament depolymerization; response to amino acid; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1072
	12631
	ENSG00000172757
	ENSMUSG00000056201
	P23528
	P18760
	NM_005507
	NM_007687
	NP_005498
	NP_031713
	Wikidata
View/Edit Human	View/Edit Mouse

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.