CHD1L

CHD1L
Identifiers
Aliases	CHD1L, ALC1, CHDL, chromodomain helicase DNA binding protein 1-like, chromodomain helicase DNA binding protein 1 like
External IDs	OMIM: 613039; MGI: 1915308; HomoloGene: 11590; GeneCards: CHD1L; OMA:CHD1L - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	147,295,765 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	97,517,519 bp
RNA expression pattern
	Top expressed in
	gonad; ; C1 segment; ; right hemisphere of cerebellum; ; right lobe of liver; ; anterior pituitary; ; ascending aorta; ; mucosa of transverse colon; ; granulocyte; ; spleen; ; Descending thoracic aorta;
	Top expressed in
	saccule; ; otic placode; ; transitional epithelium of urinary bladder; ; seminiferous tubule; ; otic vesicle; ; spermatocyte; ; spermatid; ; primitive streak; ; Paneth cell; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; hydrolase activity; ATP binding; helicase activity; DNA helicase activity;
Cellular component	plasma membrane; nucleus; nucleoplasm; cytosol;
Biological process	global genome nucleotide-excision repair; nucleotide-excision repair, DNA incision; DNA repair; cellular response to DNA damage stimulus; nucleotide-excision repair, preincision complex stabilization; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; chromatin remodeling; DNA duplex unwinding; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 3'-to lesion;
	Sources:Amigo / QuickGO
Orthologs
	9557
	68058
	ENSG00000131778
	ENSMUSG00000028089
	Q86WJ1
	Q9CXF7
NM_001256336; NM_001256337; NM_001256338; NM_001348451; NM_001348452;
	NM_001348453; NM_001348454; NM_001348455; NM_001348456; NM_001348457; NM_001348458; NM_001348459; NM_001348460; NM_001348461; NM_001348462; NM_001348463; NM_001348464; NM_001348465; NM_001348466; NM_004284; NM_024568
	NM_026539
NP_001243265; NP_001243266; NP_001243267; NP_004275; NP_078844;
	NP_001335380; NP_001335381; NP_001335382; NP_001335383; NP_001335384; NP_001335385; NP_001335386; NP_001335387; NP_001335388; NP_001335389; NP_001335390; NP_001335391; NP_001335392; NP_001335393; NP_001335394; NP_001335395
	NP_080815
	Wikidata
View/Edit Human	View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 1-like (ALC1) is an enzyme that in humans is encoded by the CHD1L gene. It has been implicated in chromatin remodeling and DNA relaxation process required for DNA replication, repair and transcription. The ALC1 comprises ATPase domain and macro domain. On the basis of homology within the ATPase domain, ALC1 belongs to Snf2 family.

It has 897 amino acids and is approximately 101kDa in size.