CHD4

CHD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N
Identifiers
Aliases	CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES
External IDs	OMIM: 603277; MGI: 1344380; HomoloGene: 68175; GeneCards: CHD4; OMA:CHD4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,614,524 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,107,554 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; epithelium of colon; ; right lobe of thyroid gland; ; anterior pituitary; ; sural nerve; ; apex of heart; ; right adrenal cortex; ; left lobe of thyroid gland; ; right coronary artery;
	Top expressed in
	Ileal epithelium; ; Rostral migratory stream; ; choroid plexus of fourth ventricle; ; tail of embryo; ; genital tubercle; ; entorhinal cortex; ; perirhinal cortex; ; neural layer of retina; ; ventricular zone; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; nucleotide binding; helicase activity; DNA helicase activity; transcription factor binding; metal ion binding; protein binding; nucleosomal DNA binding; hydrolase activity; ATP binding; histone deacetylase activity; histone deacetylase binding; zinc ion binding;
Cellular component	cytoplasm; NuRD complex; centrosome; membrane; nucleoplasm; microtubule organizing center; protein-DNA complex; cytoskeleton; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; terminal button organization; histone deacetylation; DNA duplex unwinding; regulation of signal transduction by p53 class mediator; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	1108
	107932
	ENSG00000111642
	ENSMUSG00000063870
	Q14839
	Q6PDQ2
	NM_001273; NM_001297553; NM_001363606
	NM_145979; NM_001346610
	NP_001264; NP_001284482; NP_001350535
NP_001333539; NP_666091; NP_001390521; NP_001390522; NP_001390523;
	NP_001390524; NP_001390525; NP_001390526; NP_001390527
	Wikidata
View/Edit Human	View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.