CHD8

CHD8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CKA, 2DL6
Identifiers
Aliases	CHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM
External IDs	OMIM: 610528; MGI: 1915022; HomoloGene: 72405; GeneCards: CHD8; OMA:CHD8 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,456,126 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,495,237 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; right hemisphere of cerebellum; ; granulocyte; ; ganglionic eminence; ; skin of leg; ; skin of abdomen; ; epithelium of colon; ; anterior pituitary; ; spleen;
	Top expressed in
	tail of embryo; ; genital tubercle; ; Rostral migratory stream; ; zygote; ; internal carotid artery; ; ventricular zone; ; secondary oocyte; ; external carotid artery; ; fossa; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; helicase activity; chromatin binding; methylated histone binding; hydrolase activity, acting on acid anhydrides; DNA helicase activity; protein binding; hydrolase activity; ATP binding; p53 binding; beta-catenin binding; histone binding; armadillo repeat domain binding;
Cellular component	nucleoplasm; MLL1 complex; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; brain development; digestive tract development; positive regulation of transcription by RNA polymerase III; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; DNA duplex unwinding; chromatin organization; negative regulation of Wnt signaling pathway; negative regulation of transcription, DNA-templated; canonical Wnt signaling pathway; negative regulation of apoptotic process; in utero embryonic development; startle response; social behavior; prepulse inhibition; negative regulation of fibroblast apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	57680
	67772
	ENSG00000100888
	ENSMUSG00000053754
	Q9HCK8
	Q09XV5
	NM_020920; NM_001170629
	NM_001010928; NM_201637
	NP_001164100; NP_065971
	NP_963999
	Wikidata
View/Edit Human	View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.