CHEK1

CHEK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IA8, 1NVQ, 1NVR, 1NVS, 1ZLT, 1ZYS, 2AYP, 2BR1, 2BRB, 2BRG, 2BRH, 2BRM, 2BRN, 2BRO, 2C3J, 2C3K, 2C3L, 2CGU, 2CGV, 2CGW, 2CGX, 2E9N, 2E9O, 2E9P, 2E9U, 2E9V, 2GDO, 2GHG, 2HOG, 2HXL, 2HXQ, 2HY0, 2QHM, 2QHN, 2R0U, 2WMQ, 2WMR, 2WMS, 2WMT, 2WMU, 2WMV, 2WMW, 2WMX, 2X8D, 2X8E, 2X8I, 2XEY, 2XEZ, 2XF0, 2YDI, 2YDJ, 2YDK, 2YER, 2YEX, 2YM3, 2YM4, 2YM5, 2YM6, 2YM7, 2YM8, 2YWP, 3F9N, 3JVR, 3JVS, 3NLB, 3OT3, 3OT8, 3PA3, 3PA4, 3PA5, 3TKH, 3TKI, 3U9N, 4FSM, 4FSN, 4FSQ, 4FSR, 4FST, 4FSU, 4FSW, 4FSY, 4FSZ, 4FT0, 4FT3, 4FT5, 4FT7, 4FT9, 4FTA, 4FTC, 4FTI, 4FTJ, 4FTK, 4FTL, 4FTM, 4FTN, 4FTO, 4FTQ, 4FTR, 4FTT, 4FTU, 4GH2, 4HYH, 4HYI, 4JIK, 4QYE, 4QYF, 4QYG, 4QYH, 4RVK, 4RVL, 4RVM, 5DLS, 5F4N
Identifiers
Aliases	CHEK1, CHK1, checkpoint kinase 1
External IDs	OMIM: 603078; MGI: 1202065; HomoloGene: 975; GeneCards: CHEK1; OMA:CHEK1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	125,676,255 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	36,638,361 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; ventricular zone; ; ganglionic eminence; ; buccal mucosa cell; ; testicle; ; seminal vesicula; ; stromal cell of endometrium; ; rectum; ; bone marrow;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; ureter; ; primitive streak; ; tail of embryo; ; genital tubercle; ; ventricular zone; ; abdominal wall; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; protein serine/threonine kinase activity; histone kinase activity (H3-T11 specific); protein domain specific binding;
Cellular component	cytosol; centrosome; intracellular membrane-bounded organelle; nucleoplasm; microtubule organizing center; condensed nuclear chromosome; telomere; cytoskeleton; nucleus; extracellular space; chromatin; cytoplasm; protein-containing complex;
Biological process	regulation of mitotic centrosome separation; regulation of double-strand break repair via homologous recombination; phosphorylation; replicative senescence; cellular response to DNA damage stimulus; DNA replication; protein phosphorylation; cellular response to mechanical stimulus; negative regulation of mitotic nuclear division; DNA damage induced protein phosphorylation; cell cycle; peptidyl-threonine phosphorylation; regulation of signal transduction by p53 class mediator; DNA repair; intracellular signal transduction; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; regulation of histone H3-K9 acetylation; DNA damage checkpoint signaling; positive regulation of cell cycle; apoptotic process; negative regulation of G0 to G1 transition; mitotic G2 DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	1111
	12649
	ENSG00000149554
	ENSMUSG00000032113
	O14757
	O35280
NM_001114121; NM_001114122; NM_001244846; NM_001274; NM_001330427;
	NM_001330428
	NM_007691
NP_001107593; NP_001107594; NP_001231775; NP_001265; NP_001317356;
	NP_001317357
	NP_031717
	Wikidata
View/Edit Human	View/Edit Mouse

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.